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Year : 2014  |  Volume : 1  |  Issue : 2  |  Page : 90-93

Squamoid eccrine ductal carcinoma: A diagnostic challenge

1 Department of Pathology, JSS Medical College, JSS University, Mysore, Karnataka, India
2 Department of Surgery, JSS Medical College, JSS University, Mysore, Karnataka, India

Correspondence Address:
Jayashree Krishnamurthy
#1670, 7th Cross, NS Road, Mysore, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2349-6029.147313

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Squamoid eccrine ductal carcinoma (SEDC) is a rare primary cutaneous tumor that exhibits both squamous and adnexal ductal differentiation. We report a case of SEDC presenting as multiple nodules on the scalp of a 58-year-old man. Histopathological examination of the excised lesion showed a tumor in the dermis composed of duct-like structures that represented the eccrine component and squamoid cells in nests and in an infiltrating pattern. Immunohistochemical (IHC) positivity for cytokeratin 5/6, epithelial membrane antigen (EMA), and p63 confirmed the squamoid, ductal, and primary cutaneous nature, respectively, and differentiated it from eccrine poroma, microcystic adnexal carcinoma, and porocarcinoma with squamous differentiation. With a demonstrated invasive potential, recurrent nature, and ambiguous metastatic potential, Mohs micrographic surgery, an established and successful, yet tissue-sparing surgical modality with lower recurrence rate, is the recommended treatment of choice and a close follow-up of these patients is suggested for further experiences of this tumor.

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