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 Table of Contents  
LETTER TO EDITOR
Year : 2019  |  Volume : 6  |  Issue : 1  |  Page : 64

Generalized eruptive histiocytosis in a child: A rare entity


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Web Publication13-Jun-2019

Correspondence Address:
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdpdd.ijdpdd_78_18

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How to cite this article:
Al-Mendalawi MD. Generalized eruptive histiocytosis in a child: A rare entity. Indian J Dermatopathol Diagn Dermatol 2019;6:64

How to cite this URL:
Al-Mendalawi MD. Generalized eruptive histiocytosis in a child: A rare entity. Indian J Dermatopathol Diagn Dermatol [serial online] 2019 [cited 2019 Jun 17];6:64. Available from: http://www.ijdpdd.com/text.asp?2019/6/1/64/260197



Sir,

I read with interest the case report by Kar et al.[1] on the generalized eruptive histiocytosis (GEH) in an Indian child. I assume that the rare presentation of GEH in a young child should alert the authors to consider impaired immune status. Among conditions associated with impaired immunity, infection with human immunodeficiency virus (HIV) is of prime importance. My assumption is based on the following point. It is obvious that individuals infected with HIV are more susceptible to a wide range of proliferative disorders (PDs) compared to immune-competent counterparts. To my knowledge, India is among Asian countries noticeably affected with HIV. Although no recent data are yet present on the exact pediatric HIV seroprevalence in India, pediatric HIV is poised to become a major public health problem in India with the rising trend of HIV infection in pregnant. The seroprevalence of HIV infection among Indian pregnant was reported to be substantial (1.03%).[2] Children with perinatal exposure to HIV were found to be at increased risk to various PDs compared to nonexposed counterparts.[3] Among PDs, histiocytosis has been reported in HIV-positive pediatric patients.[4] Regrettably, the HIV status of the studied child and mother was not defined. I presume that some sort of vertical HIV transmission to the child ought to be considered by the authors. Hence, the measurements of blood CD4 lymphocyte count and viral overload in the studied child were solicited. If these measurements were accomplished and they revealed HIV infection, the case in question could be truly considered a novel case report of HIV-associated GEH in India.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Kar C, Biswas R, Banerjee S, Sarkar P, Shome K, Das KD. Generalized eruptive histiocytosis in a child: A rare entity. Indian J Dermatopathol Diagn Dermatol 2018;5:143-5.  Back to cited text no. 1
  [Full text]  
2.
Sibia P, Mohi MK, Kumar A. Seroprevalence of human immunodeficiency virus among antenatal women in one of the institute of Northern India. J Clin Diagn Res 2016;10:QC08-9.  Back to cited text no. 2
    
3.
Kest H, Brogly S, McSherry G, Dashefsky B, Oleske J, Seage GR 3rd, et al. Malignancy in perinatally human immunodeficiency virus-infected children in the United States. Pediatr Infect Dis J 2005;24:237-42.  Back to cited text no. 3
    
4.
Seth R, Selvam P, Jain R, Gosh R, Arun J, Lodha R, et al. Langerhans cell histiocytosis in a pediatric HIV patient. Virusdisease 2015;26:200-2.  Back to cited text no. 4
    




 

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