Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login
  • Users Online: 138
  • Home
  • Print this page
  • Email this page
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
   Table of Contents - Current issue
Coverpage
January-June 2020
Volume 7 | Issue 1
Page Nos. 1-55

Online since Thursday, June 4, 2020

Accessed 5,782 times.

PDF access policy
Journal allows immediate open access to content in HTML + PDF
View as eBookView issue as eBook
Access StatisticsIssue statistics
RSS FeedRSS
Hide all abstracts  Show selected abstracts  Export selected to  Add to my list
EDITORIAL  

Growing pains and growth spurt p. 1
Rajalakshmi Tirumalae
DOI:10.4103/ijdpdd.ijdpdd_58_20  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta
ORIGINAL ARTICLES Top

Evaluation of active and stable stages of vitiligo using S-100 and human melanoma black-45 immunostains Highly accessed article p. 2
Gurpinder Kaur, Rajpal Singh Punia, Reetu Kundu, Gurvinder Pal Thami
DOI:10.4103/ijdpdd.ijdpdd_44_19  
Background: Vitiligo is the most prevalent pigmentary disorder occurring worldwide. In most cases, the diagnosis is made by clinical examination alone. The disease status (active/stable) needs to be assessed to make appropriate therapeutic decisions. Objective: The aim of the present study was to evaluate the histopathological and immunohistochemical features in active and stable lesions. Materials and Methods: Biopsies from vitiliginous areas from 50 patients (25 each of clinically active and stable vitiligo); with hematoxylin and eosin, Masson Fontana (MF), S-100, and human melanoma black-45 (HMB-45) stained sections were studied. Results: Age of the patients ranged from 7 to 69 years (mean age: 33.6 ± 15.73 years). Of 50 patients, 27 (54%) were male and 23 (46%) were female. All the cases showed variable degree of basal hypopigmentation. Histopathological findings, epidermal spongiosis, basal vacuolar degeneration, dermal melanophages, and dermal lymphomononuclear cells were commonly observed in active lesions as compared to the stable ones. On MF staining, 23/25 cases (92%) of active vitiligo showed complete loss of basal melanin. Quantitative analysis of HMB-45 immunostaining in stable and active vitiligo revealed mean number of positive melanocytes as 2.52 ± 1.0/high power field (hpf) and 0.08 ± 0.28/hpf, respectively, while on S-100 immunostaining the mean values of positive Langerhans cells were 1.70 ± 0.38/hpf and 7.78 ± 4.11/hpf, respectively. Conclusion: The demonstration of overall reduction in the number of HMB-45-positive melanocytes and increase in S-100-positive Langerhans dendritic cells in the active vitiligo lesions is facilitated by immunohistochemistry. The technique is of immense help in differentiating active and stable stages of vitiligo, thus guiding therapy.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

A possible role of WNT5A expression in papulosquamous skin diseases Highly accessed article p. 7
Laila Mansour Mohamed, Eiman Adel Hasby, Hagar Ahmed Kassem, Nashwa Naeem Elfar
DOI:10.4103/ijdpdd.ijdpdd_59_19  
Background: Wnt genes code for a family of secreted, lipid-modified glycoproteins. Wnt5a has important functions in cell proliferation, fate determination, and differentiation. Dysregulation of Wnt5a signaling implicated in multiple disease. Aim of Work: The aim is to elucidate the possible role of Wnt5a in pathogenesis of papulosquamous skin disorders through the evaluation of its expression immunohistochemically. Patients and Methods: This study included 80 patients with various papulosquamous diseases (psoriasis, lichen planus, ptyriasis rosea, and ptyriasis rubra pilaris), in addition to 20 healthy controls served as control. Punch skin biopsies were taken from all individuals for immunohistochemical staining with Wnt5a. Results: There was a highly statistically significant upregulation in Wnt5a expression in all stained skin specimens of the studied papulosquamous diseases in both epidermis and dermal lymphocytes compared to normal control. Conclusion: The upregulated expression of Wnt5a indicated its involvement in pathogenesis of papulosquamous diseases. Wnt5a and/or its receptor can be a challenging target for therapeutic intervention. Regular follow-up for these patients is recommended as Wnt5a also may be involved in their malignant transformation.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta
CASE REPORTS Top

Angiolymphoid hyperplasia with eosinophilia: Simultaneous presence of lesions of two different morphologies p. 16
Reena Kumari Sharma, Mudita Gupta, Anchana Gulati, Samriti Sood
DOI:10.4103/ijdpdd.ijdpdd_18_19  
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular tumor which presents as a dermal papule or a nodule over the head-and-neck region. Histopathologically, there is vascular proliferation in the upper dermis and diffuse lymphocytic infiltrate with eosinophilia. Kimura's disease is the closest differential of ALHE, which presents as subcutaneous nodules. We report a case of ALHE presenting with a violaceous papule overlying a subcutaneous nodule, histopathologically; both lesions were diagnosed as ALHE.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Genital porokeratosis: A report of two cases and review of literature p. 19
Rakesh P Roge, Sumit A Hajare, Jayesh I Mukhi, Rajesh P Singh
DOI:10.4103/ijdpdd.ijdpdd_29_19  
Porokeratosis (PK) is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. Genital involvement in PK is a rare occurrence even in disseminated forms. We encountered two patients who had PK primarily affecting the genital area. Both cases were males out of which one case had involvement of the scrotum and thigh and other case had only scrotal involvement. The cases were difficult to diagnose clinically, but dermoscopy was helpful and was further confirmed on histopathology.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Benign fibrohistiocytic tumour of the palate p. 23
Nilima Sharma, Mohammad Jaseem Hassan
DOI:10.4103/ijdpdd.ijdpdd_12_19  
Benign fibrous histiocytomas of soft tissue are composed of spindled fibroblasts admixed with secondary elements including histiocytes, foam cells, and inflammatory cells. These tumors occur equally in males and females and most often arise in the dermis and subcutaneous tissues. We report a rare case of benign fibrous histiocytic tumor of the palate with histologic features and immunohistochemical characteristics.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Multiple oral verruciform xanthomas: A rare entity p. 27
Jayati Shailesh Dave, Sunanda Arun Mahajan, Atul M Dongre, Meghana Rane
DOI:10.4103/ijdpdd.ijdpdd_31_20  
Verruciform xanthoma (VX) is an uncommon benign lesion that can affect oral, genital mucosa, and rarely skin. The characteristic foam cells seen in papillary dermis are a hallmark for diagnosing this entity. A 42-year-old male, tobacco-chewer presented with asymptomatic white-circular plaques on the bilateral buccal mucosa and yellow papules on retromolar area which on histopathological evaluation showed parakeratotic epithelium with surface and deep invagination of columns of parakeratosis throughout the hyperplastic epidermis, few neutrophils in upper spinous layers, and uniform elongation of rete ridges. The rete ridges showed numerous lipid-laden CD 68-positive foam cells. Punch excision coupled with cryotherapy was done, which resulted in the complete resolution of lesions. We publish this uncommon benign entity for increased awareness among physicians to consider it as a differential of verrucous lesion in the mucosa. Our patient had two different morphology of lesions, both suggestive of VX with characteristic foam cells on histopathology.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Acrokeratoelastoidosis in hansen's disease: A new insight p. 30
Vrutika Hasmukh Shah, Kinjal D Rambhia, Jayesh I Mukhi, Rajesh P Singh
DOI:10.4103/ijdpdd.ijdpdd_6_20  
Acrokeratoelastoidosis (AKE), first described by Costa in 1953, is characterized by small, firm, keratotic papules with central umbilication along the borders of the hands and feet. It is a type of palmoplantar marginal papular keratoderma and needs to be differentiated from other marginal papular keratodermas. AKE can be inherited or sporadic, with predisposing factors being excessive sun exposure, hyperhidrosis, and repetitive trauma. We here describe a case of AKE in a leprosy patient with probably secondary to repetitive chronic trauma due to loss of sensory function.
[ABSTRACT]  [HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta
LETTER TO EDITORS Top

An unusual case of amelanotic melanoma in a young female Highly accessed article p. 33
Manika Khare, Jai Wade, Abhishek Pareek
DOI:10.4103/ijdpdd.ijdpdd_8_19  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Varied presentation of cutaneous tuberculosis in a patient p. 36
Seema Rani, Prekshi Bansal, Arvind Ahuja, Diksha Agrawal
DOI:10.4103/ijdpdd.ijdpdd_63_19  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Multiple giant tuberous xanthomas with type IIa hypercholesteremia in a young male p. 38
Niharika Jha, Vanya Narayan
DOI:10.4103/ijdpdd.ijdpdd_40_20  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Malignant Proliferating Trichilemmal Tumor: A Rare Adnexal Neoplasm p. 40
Bhavya P Mohan, V Letha, V Anilkumar
DOI:10.4103/ijdpdd.ijdpdd_54_19  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

A challenging case of clear cell hidradenoma of thumb Highly accessed article p. 42
Hemant Kumar Sharma, Shivani Prashar
DOI:10.4103/ijdpdd.ijdpdd_29_20  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Curious case of coexistence of erythema induratum and penile papulonecrotic tuberculid p. 44
Molisha Bhandari, Geeti Khullar, Shruti Sharma, V Ramesh
DOI:10.4103/ijdpdd.ijdpdd_36_20  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Coincidence of two minor tissue reaction patterns: Eosinophilic flame figures and transepidermal elimination in histopathology of arthropod bite reaction p. 46
Saba Moghadas, Negar Bahrololoumi Bafruee, Maryam Nasimi, Alireza Ghanadan
DOI:10.4103/ijdpdd.ijdpdd_62_18  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Nodules in the nose: An unusual location of warty dyskeratoma p. 48
Paras Choudhary, Bhushan A Darkase, Atul Dongre, Uday Khopkar
DOI:10.4103/ijdpdd.ijdpdd_19_20  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Punctate porokeratosis presenting as papules along palmar and plantar creases p. 50
Azra N Fathima, Anuradha Priyadarshini, Mahalakshmi Veeraraghavan, Murugan Sundaram
DOI:10.4103/ijdpdd.ijdpdd_61_19  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta
LETTERS TO EDITOR Top

Cystic follicular hamartoma: A rare case report p. 52
Chirag Ashwin Desai, Saurabh Shah
DOI:10.4103/ijdpdd.ijdpdd_44_20  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta
LETTER TO EDITORS Top

A case of papular acantholytic dyskeratosis in a young male p. 54
Anuradha Jindal, Venkataram Mysore, Malcom Noronha
DOI:10.4103/ijdpdd.ijdpdd_57_19  
[HTML Full text]  [PDF]  [Mobile Full text]  [EPub]  [Sword Plugin for Repository]Beta

Subscribe this journal
Submit articles
Most popular articles
Joiu us as a reviewer
Email alerts
Recommend this journal