Indian Journal of Dermatopathology and Diagnostic Dermatology

: 2019  |  Volume : 6  |  Issue : 1  |  Page : 14--24

“Interface” Dermatoses: Revisited

Sasi Kiran Attili 
 Visakha Institute of Skin and Allergy, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Dr. Sasi Kiran Attili
Visakha Institute of Skin and Allergy, Maharanipeta, Visakhapatnam, Andhra Pradesh

“Interface dermatoses” are defined as inflammatory dermatoses primarily affecting the interface elements along the dermoepidermal junction, resulting in epidermal basal cell damage. This epidermal basal cell damage can be of two forms: vacuolar/hydropic degeneration and filamentous degeneration (resulting in Civatte bodies). This may be associated with a range of secondary epidermal (atrophy to hypertrophy) and dermal changes (varying from simple effacement of the rete ridges to the diffuse dermal fibrosis/sclerosis). With so many variables, “Interface dermatitis” per se is not a diagnosis by itself but simply a reaction pattern, similar to “psoriasiform dermatitis” or “spongiotic dermatitis.” One should never use these terms as the final sign out diagnosis in reports, though in difficult cases one may allude to the reaction pattern and discuss the possible differentials. This article analyzes and discusses in detail, the basic pathogenesis behind the primary/secondary features associated with interface dermatoses and the steps involved in their histopathological evaluation; thorough knowledge of which may help one arrive at a specific diagnosis.

How to cite this article:
Attili SK. “Interface” Dermatoses: Revisited.Indian J Dermatopathol Diagn Dermatol 2019;6:14-24

How to cite this URL:
Attili SK. “Interface” Dermatoses: Revisited. Indian J Dermatopathol Diagn Dermatol [serial online] 2019 [cited 2019 Oct 20 ];6:14-24
Available from:;year=2019;volume=6;issue=1;spage=14;epage=24;aulast=Attili;type=0