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 Table of Contents  
CASE REPORT
Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 7-13

Clinical and histological comparison of ulcerated lichen planus and chronic cutaneous lupus erythematosus: Aseries of six cases


1 Delhi Dermatology Group, New Delhi, India
2 Rashmi Medical Centre, New Delhi, India
3 Vision Research Foundation, Chennai, Tamil Nadu, India

Date of Web Publication14-Jun-2016

Correspondence Address:
Meenakshi Batrani
Delhi Dermatology Group, 10, Aradhana Enclave, R. K. Puram, Sector 13, New Delhi - 110 066
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-6029.184006

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  Abstract 

Cutaneous ulceration as the primary manifestation of chronic cutaneous lupus erythematosus (CCLE) and lichen planus (LP) is uncommon. In the absence of typical lesions, clinical diagnosis is challenging. We report six cases, three each of, CCLE and LP that presented with cutaneous ulcers. A detailed comparison of clinical and histopathological features between two groups was conducted. The statistical significance of comparative features could not be assessed because of small number of cases. In view of clinical and histopathological overlap, diagnosis requires clinico-pathological correlation and ancillary tests including direct immunofluorescence and antinuclear antibodies.

Keywords: Cutaneous ulcer, erosion, lichen planus, lupus erythematosus


How to cite this article:
Batrani M, Kubba A, Kubba R, Chandra K, Subramanian K. Clinical and histological comparison of ulcerated lichen planus and chronic cutaneous lupus erythematosus: Aseries of six cases. Indian J Dermatopathol Diagn Dermatol 2016;3:7-13

How to cite this URL:
Batrani M, Kubba A, Kubba R, Chandra K, Subramanian K. Clinical and histological comparison of ulcerated lichen planus and chronic cutaneous lupus erythematosus: Aseries of six cases. Indian J Dermatopathol Diagn Dermatol [serial online] 2016 [cited 2020 Nov 26];3:7-13. Available from: https://www.ijdpdd.com/text.asp?2016/3/1/7/184006


  Introduction Top


Cutaneous ulcers are challenging with respect to diagnosis and treatment because of heterogeneous etiopathogenesis. Cutaneous ulcers due to chronic cutaneous lupus erythematosus (CCLE) and lichen planus (LP) are infrequent.[1]

CCLE has many subtypes, mainly classic discoid lupus erythematosus (DLE), lupus hypertrophicus, lupus profundus, and chilblain lupus. Superimposed ulcerations can develop over cutaneous lesions of CCLE, particularly, chilblain lupus which may develop small overlying erosions and lupus profundus [2](ulceration described in 28% cases of lupus profundus in one series).[3] However, ulcer as the only or predominant presentation of CCLE is rare.

Cutaneous ulcerated LP is an unusual variant, predominantly, involving plantar surface, usually associated with anonychia.[4] Ulcerated cutaneous LP of non-acral sites is even rarer.

We present six unusual cases of ulcerated CCLE and LP.


  Case Report Top


Clinical details of all the cases are summarized in [Table 1].
Table 1: Clinical details of cutaneous ulcerated chronic cutaneous lupus erythematosus and lichen planus cases

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Ulcerated lupus erythematosus cases

Three cases of ulcerated CCLE included two women and one man, aged 22–41 years. Duration of illness ranged from 3 months to 10 years. All three patients presented with skin ulcers. Ulcers numbering two to multiple (>5), involved scalp, arms, abdomen, buttock, thigh, and leg ([Figure]a, [Figure 1]b and [Figure 2]a, [Figure 2]d). Additional findings noted on cutaneous examination were macular pigmentation on the cheeks in Case 1 [Figure 1]c and atrophic scars in Case 3.
Figure 1: Case 1: (a and b) Irregular ulcers with violaceous borders on leg and buttock; (c) macular pigmentation on cheek; (d and e) after 6 months of treatment, scars of healed ulcers with pigmented rims, on leg and buttock

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In all three cases, broad clinical differential diagnoses, particularly, mycobacterial and deep fungal infections were considered. CCLE was included in the clinical differential diagnosis in two cases.

Skin biopsies (number of biopsies: 1–3/patient) were performed in all three cases. Case 1 presented to us for a second opinion with a histopathological diagnosis of squamous cell carcinoma, reported elsewhere, which on review, was interpreted as pseudoepitheliomatous hyperplasia. Subsequently, two more biopsies were performed, the one from the center of ulcer was non-contributory, and the one from the edge was diagnostic of lupus erythematosus (LE)[Figure 3]. The diagnosis was confirmed by a positive lupus band of immunoglobulin M and C3 on direct immunofluorescence (DIF) study and raised antinuclear antibodies (ANA)(133, normal level <20) and dsDNA levels (64.13, normal <35). In Case 2, the first biopsy was initially misinterpreted as hypertrophic L P. In view of patient developing typical DLE plaques over a period of 1year and raised ANA levels, the second biopsy and review of the initial biopsy were done, and diagnosis was revised to LE [Figure 2]b and [Figure 2]c. A diagnosis of LE was given in Case 3 based on the histopathological findings [Figure 2]e and [Figure 2]f but, the patient was lost to follow-up, and no further confirmatory tests could be done.
Figure 3: Case 1:(a) Pseudoepitheliomatous hyperplasia, lichenoid infiltrate, superficial and deep dermal perivascular and periadnexal infiltrate, H and E, ×25; (b) interface pathology with basal layer vacuolization and apoptotic keratinocytes, H and E, ×200

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Figure 2: Case 2(a-c):(a) Hyperkeratotic plaque with central ulceration on the leg;(b) pseudoepitheliomatous epidermal hyperplasia and inset showing interface pathology, H and E, ×40; inset×200;(c) increased dermal mucin, alcian blue, ×100. Case 3(d-f):(d) Atrophic scars with central ulceration on the back;(e) superficial and deep perivascular and periadnexal infiltrate, H and E, ×25;(f) atrophic epidermis with squamatized basal layer and increase dermal mucin, H and E, ×20

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Treatment details were available only for Case 1; the patient was initially started on hydroxychloroquine with oral and topical steroids, and later on, she was managed on azathioprine. Her lesions improved significantly over a period of few months, ulcers healed and were replaced by scars with hyperpigmented rim [Figure 1]d and [Figure 1]e.

Ulcerated lichen planus cases

Three cases of ulcerated LP included two women and one man in 18–41 years age group. Case 4 had a single lesion, a large ulcer on the shin, for 4 years [Figure 4]a. The ulcer healed leaving a thin central crust, after 3 months of oral and topical steroid therapy [Figure 4]b. Case 5, an adolescent, presented with 4–5 months history of multiple papules and plaques of LP showing koebnerization on the arms, legs, and ankles. Few ulcerated papules, present on the legs, were suspected to be secondary to mechanical/chemical manipulation [Figure 5]a. Skin lesions responded to oral hydroxyzine and topical steroid after 1 month of therapy. Case 6 had multiple papules and nodules on both legs for over16 years, and one of the lesions on the shin had insidiously progressed to a large ulcer [Figure 5]c. The patient was started on oral Cyclosporine, and the ulcer healed over a period of few months.
Figure 4: Case 4:(a) Ulcer surrounded by hyperkeratotic pigmented margins on knee;(b) healed ulcer after 2 months of treatment;(c) epidermal hyperplasia and lichenoid infiltrate, H and E, ×40;(d) orthokeratotic hyperkeratosis, wedge-shaped hypergranulosis, and lichenoid interface pathology, H and E, ×100

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Figure 5: Case 5(a and b):(a) Papule with central erosion on the leg; (b) orthokeratotic hyperkeratosis, epidermal acanthosis with wedge-shaped hypergranulosis and lichenoid interface pathology, H and E, ×40. Case 6 (c and d):(c) Ulcerated plaque on leg and adjacent papular lesion; (d) hyperkeratosis and lichenoid interface pathology, H and E, ×4

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In all three cases, varied clinical diagnoses were raised. In Cases 5 and 6, LP was considered as the most likely diagnosis because of the presence of accompanying typical LP lesions, whereas, in Case 4, LP was not suspected clinically.

In all three cases, two biopsies were performed one from the ulcer center and the other from either the ulcer edge (Cases 4 and 6) or non-ulcerated papular lesion (Cases 5.) In all cases, biopsies from edge/non-ulcerated lesion yielded the diagnostic features of LP [Figure 4]c, [Figure 4]d and [Figure 5]b, [Figure 5]d while biopsies from ulcer center were non-diagnostic. DIF study was done in one patient (Case 4) which was negative for lupus band.

Clinical comparison of ulcerated chronic cutaneous lupus erythematosus and lichen planus

The mean age of CCLE patients was 31.6 years which was higher than the mean age of 24 years for LP patients. There was no difference in sex distribution of the cases in both categories. Interestingly, the site of ulceration in all three cases of LP was anterior leg whereas, in LE, the distribution of ulcer was more widespread. At initial presentation, none of the LE cases showed typical lesions of CCLE while two out of three cases of LP had typical lesions in addition to the ulcer. Morphology of cutaneous ulcer was similar in both groups except Case 5, who had eroded papules of LP.

Histopathological comparison of ulcerated chronic cutaneous lupus erythematosus and lichen planus

The comparative features are summarized in [Table 2]. Interface pathology was observed in both ulcerated LP and CCLE. In all but one case (Case 2 of CCLE), there was a dense lichenoid infiltrate in the papillary dermis. Similarly, capillary proliferation and mild papillary dermal edema were focally seen in both groups where biopsy site was the leg. Therefore, this finding is likely to be secondary to ulceration and/or site. Additional features such as plasma cells, mild deep dermal infiltrate, and mild basement membrane thickening on periodic acid–Schiff stain were variably seen in both groups.
Table 2: Comparison of histopathological findings in ulcerated lichen planus and chronic cutaneous lupus erythematosus

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Distinctive features seen only in CCLE cases were dense dermal perivascular/periadnexal infiltrate, increased dermal mucin, epidermal atrophy, or marked pseudoepitheliomatous hyperplasia with keratinocyte pallor and prominent basement membrane thickening. Features specific to LP cases were compact orthokeratotic hyperkeratosis, wedge-shaped hypergranulosis, and saw-toothed epidermal hyperplasia. Although the epidermal changes seem to be somewhat different in two diseases, it is difficult to entirely ascribe this feature to the disease per se as these might be related to the duration of the lesion and the site of the biopsy.

The statistical significance of the observed clinical and histopathological differences cannot be assessed because of small number of cases.


  Discussion Top


The clinical diagnosis of LP and CCLE is particularly challenging when cutaneous ulcer is the only manifestation, as exemplified in patients 1–4 of present series. Even in the absence of typical lesions, subtle clues may be observed in some cases. For example, in Case 1, macular pigmentation on the cheek (a feature sometimes seen in Indian patients),[5] and atrophic scars in Case 3 led to clinical suspicion of CCLE. The clinical differential diagnoses for cutaneous ulceration are wide and particularly in the Indian setting, infectious etiologies'(mycobacterial and fungal) are prime considerations. The diagnosis relies primarily on histopathology and therefore appropriate site and adequate depth of biopsy are crucial for diagnosis. The edge of the ulcer should be biopsied instead of the center which is non-diagnostic.

Histopathologically, LP and CCLE may show overlapping features. In ulcerated lesions, the distinction becomes more difficult because of secondary changes. For instance, dermal mucin, an important clue to LE, is often present in granulation tissue and scars. Thus, mucin should be assessed in interstitial reticular dermis away from these areas. Other findings that are supportive of CCLE, such as deep dermal inflammation, plasma cells, papillary dermal edema, and telangiectasias, may also be seen as reactive changes along the ulcer margins. In dubious cases, clinico-pathological correlation and ancillary investigations, i.e.,DIF and serology for (ANA and dsDNA) play an important role in making a definitive diagnosis.

Cutaneous ulcer is a rare morphological variant of CCLE. In a review by Pramatarov on clinical subtypes of CCLE, ulcerated form was not enlisted among more than twenty different subtypes of CCLE.[6] Ulcerated CCLE has rarely been documented in literature. In a study by Bajaj et al. comprising 110 patients of CCLE, ulcerative form constituted 7.3%.[7] A case of ulcerated CCLE involving ear lobe in the absence of other classic features i.e.,atrophy or scarring, has been described.[8] Green and Pasternak have reported a case wherein multiple typical DLE lesions were present and one lesion on the hand progressed to hypertrophic plaque with extensive erosion.[9] Rai and Balachandran reported an Indian patient who presented with a large non-healing ulcer on the back along with smaller scaly depressed plaques of DLE over arms, thighs, and macular hyperpigmentation on the zygomatic area.[10] Macular hyperpigmentation as in this case and in one of our patients (Case 1) may be a manifestation of CCLE, particularly, in patients of Indian ethnicity.[5]

Erosive plantar LP was first described by Friedman in 1921.[11] Albeit, many times, it has been termed as erosive palmoplantar LP, the involvement of palms is very rare.[4] The erosive plantar LP is a crippling, cicatricial dermatosis manifesting as hypertrophic and bullous lesions on the plantar surface of foot and dorsum of toes, leading to superficial ulceration and anonychia. The disease mainly affects adults and is more common in women than in men. It is usually accompanied by mucosal LP, papulo-squamous LP and cicatricial alopecia.[4],[11] Erosive LP is known to be associated with various autoimmune diseases such as diabetes, chronic liver disease, primary biliary cirrhosis, Hashimoto thyroiditis, rheumatoid arthritis, Sjogren's syndrome, abnormal autoantibody profile and Hepatitis C.[4],[11],[12]

Ulcerative cutaneous LP at non-acral sites is exceptionally rare. The Internet-based search yielded 15 cases,[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23],[24],[25],[26],[27] summarized in [Table 3]. Surprisingly, two cases of severe generalized ulcerative LP, complicated by secondary infections leading to death, have been documented.[16],[19] Pathergy was observed in one patient.[18] Similar to one of our cases (Case 5), in a report by Schepis et al.,[23] the lesions were suspicious for factitious dermatitis.
Table 3: Nonacral cutaneous ulcerated lichen planus cases reported in literature

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Associated autoimmune diseases and Hepatitis C have been documented in five of the 15 reported cases of ulcerated LP (four Hepatitis C and one Sjogren syndrome).[15],[20],[22],[24],[25] In the present series, there was no known history of autoimmune disease or Hepatitis C in any of the pateints; however, patients were not specifically, investigated for this.

The various treatment options for ulcerated LP are systemic and topical or intralesional steroids, cyclosporin, oral and topical retinoids, thalidomide, tacrolimus, topical tetracycline, azathioprine, griseofulvin, dapsone, chloroquine, low molecular weight heparin, platelet derived growth factor, ultraviolet A phototherapy, and extracorporeal photochemotherapy.[4],[11],[12],[17],[20] Acral ulcerative LP is notoriously recalcitrant to treatment, at times requiring skin grafting.[4] However, in non-acral cutaneous ulcerative LP, as reviewed from the published reports and our experience from this series, the results seem to be promising with satisfactory response in most.

Hypertrophic ulcerated CCLE is managed with oral antimalarials (combining two antimalarials including quinacrine with hydroxychloroquine or chloroquine), oral retinoids, topical steroids, and thalidomide.[9]

Squamous cell carcinoma (SCC) is a documented risk in both DLE,[28] and LP, particularly its hypertrophic and ulcerative variants.[4],[29] The development of squamous cell carcinoma on a preexisting lesion of DLE and LP might be the cause of ulceration. Therefore, biopsy in ulcerated lesions is of utmost importance. Any suspicious or clinically different looking area should be biopsied to exclude SCC. On the contrary, pseudoepitheliomatous hyperplasia and keratinocytic atypia seen in hypertrophic lesions of DLE may lead to misdiagnosis of SCC on histology,[28] as also happened in Case 1 of this series.


  Conclusion Top


Ulcerated LP and CCLE are uncommon causes of cutaneous ulcers. In the absence of typical skin lesions, LP/CCLE as the underlying cause of cutaneous ulcer may not be suspected clinically. Diagnosis is based on histopathology in conjunction with DIF and antinuclear antibodies.

Acknowledgment

The authors wish to thank Dr.Ahmed Zaheer and Dr.Arvind Kaul (Case 2); Dr.Anupama Bisaria (Case 3); Dr.V. Venugopal Reddy (Case 6), for contributing clinical details and clinical photographs.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Mekkes JR, Loots MA, Van Der Wal AC, Bos JD. Causes, investigation and treatment of leg ulceration. Br J Dermatol 2003;148:388-401.  Back to cited text no. 1
    
2.
Kuhn A, Sticherling M, Bonsmann G. Clinical manifestations of cutaneous lupus erythematosus. J Dtsch Dermatol Ges 2007;5:1124-37.  Back to cited text no. 2
    
3.
Ishiguro N, Iwasaki T, Kawashima M, Kawakami M. Intractable ulceration in a patient with lupus erythematosus profundus successfully treated with cyclosporine. Int J Dermatol 2012;51:1131-3.  Back to cited text no. 3
    
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Hoffman MD. A typical ulcers. Dermatol Ther 2013;26:222-35.  Back to cited text no. 4
    
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Costner MI, Sontheimer RD. Lupus erythematosus. In: Wolf K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick's Dermatology in General Medicine. 7thed. New York: The McGraw-Hill Companies; 2008. p.1515-35.  Back to cited text no. 5
    
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Pramatarov KD. Chronic cutaneous lupus erythematosus–Clinical spectrum. Clin Dermatol 2004;22:113-20.  Back to cited text no. 6
    
7.
Bajaj DR, Devrajani BR, Matlani BL. Discoid lupus erythematosus: A profile. J Coll Physicians Surg Pak 2010;20:361-4.  Back to cited text no. 7
    
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Valencia X, Kraus A. Clinical images: Ear ulceration in discoid lupus erythematosus. Arthritis Rheum 1995;38:1712.  Back to cited text no. 8
    
9.
Green PJ, Pasternak S. Hypertrophic and ulcerated discoid lupus erythematosus. J Cutan Med Surg 2012;16:453-7.  Back to cited text no. 9
    
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Rai VM, Balachandran C. Non-healing ulcer on the back of a man. Dermatol Online J 2006;12:23.  Back to cited text no. 10
    
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Goucha S, Khaled A, Bennani Z, Rammeh S, Zéglaoui F, Zermani R, et al. Erosive lichen planus of the soles: Effective response to prednisone. Dermatol Ther (Heidelb) 2011;1:20-4.  Back to cited text no. 11
    
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Ojeda T, Rodríguez-Rey E, Camacho FM. Ulcerative lichen planus of the sole treated with tacrolimus, 0.1%. Actas Dermosifiliogr 2011;102:383-4.  Back to cited text no. 12
    
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Altman J, Perry HO. The variations and course of lichen planus. Arch Dermatol 1961;84:179-91.  Back to cited text no. 13
    
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Higgins CR, Handfield-Jones S, Black MM. Erosive, flexural lichen planus–An uncommon variant. Clin Exp Dermatol 1993;18:169-70.  Back to cited text no. 14
    
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Brudy L, Janier M, Reboul D, Baviera E, Bonvalet D, Daniel F. Erosive lichen of the scalp. Ann Dermatol Venereol 1997;124:703-6.  Back to cited text no. 15
    
16.
Matsuura A, Takenaka H, Yasuno H, Kishimoto S. Severe generalized ulcerative lichen planus. Acta Derm Venereol 2003;83:145-6.  Back to cited text no. 16
    
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Eisman S, Orteu CH. Recalcitrant erosive flexural lichen planus: Successful treatment with a combination of thalidomide and 0.1% tacrolimus ointment. Clin Exp Dermatol 2004;29:268-70.  Back to cited text no. 17
    
18.
Henderson RL Jr., Williford PM, Molnar JA. Cutaneous ulcerative lichen planus exhibiting pathergy, response to acitretin. J Drugs Dermatol 2004;3:191-2.  Back to cited text no. 18
    
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Sheth N, Bull R, Cerio R, Harwood C, O'Toole E, Paige D, et al. Fatal erosive lichen planus. Br J Dermatol 2006;155:1075-6.  Back to cited text no. 19
    
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Neville JA, Hancox JG, Williford PM, Yosipovitch G. Treatment of severe cutaneous ulcerative lichen planus with low molecular weight heparin in a patient with hepatitis C. Cutis 2007;79:37-40.  Back to cited text no. 20
    
21.
Schepis C, Siragusa M, Lentini M. Erosive lichen planus: Two uncommon cases. Acta Derm Venereol 2008;88:268-70.  Back to cited text no. 21
    
22.
Franchi C, Frigerio E, Spadino S, Garutti C, Colombo DM, Altomare A, et al. Hepatitis C viral load decreases after cyclosporin treatment for erosive lichen planus. Clin Exp Dermatol 2009;34:e254-5.  Back to cited text no. 22
    
23.
Schepis C, Lentini M, Siragusa M. Erosive lichen planus on an atypical site mimicking a factitial dermatitis. Acta Derm Venereol 2010;90:185-6.  Back to cited text no. 23
    
24.
Fisher V, Fernandez MP, Krejci-Manwaring J. Lichen planus mimicking recalcitrant ulcerative psoriasis: When is it time to biopsy? Cutis 2013;92:136-9.  Back to cited text no. 24
    
25.
Binesh F, Parichehr K. Erosive lichen planus of the scalp and hepatitis C infection. J Coll Physicians Surg Pak 2013;23:169.  Back to cited text no. 25
    
26.
Patel N, Padhiyar J, Jain A, Shah Y. Excellent response to oral acitretin in cutaneous ulcerative lichen planus. GCSMC J Med Sci 2013;2:34-5. Available from: . [Last accessed on 2014 Jun 15].  Back to cited text no. 26
    
27.
Mansouri Y, Kaur MR, Paul M, Muc R. Solitary ulcerative lichen planus on the lower leg, a diagnostic challenge. J Am Acad Dermatol 2014;70 Suppl 1:AB55.  Back to cited text no. 27
    
28.
Zedek DC, Smith ET Jr., Hitchcock MG, Feldman SR, Shelton BJ, White WL. Cutaneous lupus erythematosus simulating squamous neoplasia: The clinicopathologic conundrum and histopathologic pitfalls. J Am Acad Dermatol 2007;56:1013-20.  Back to cited text no. 28
    
29.
Castaño E, López-Ríos F, Alvarez-Fernández JG, Rodríguez-Peralto JL, Iglesias L. Verrucous carcinoma in association with hypertrophic lichen planus. Clin Exp Dermatol 1997;22:23-5.  Back to cited text no. 29
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]



 

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