|Year : 2018 | Volume
| Issue : 1 | Page : 54-56
Cutaneous metastasis of gastric carcinoma: A rare case with unusual presentation site
Fariba Abbasi1, Ata Abbasi2, Rahim Mahmodlou3, Elnaz Mehdipour2
1 Department of Pathology, Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3 Department of Surgery, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
|Date of Web Publication||22-May-2018|
Dr. Ata Abbasi
Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia
Source of Support: None, Conflict of Interest: None
Skin metastases are relatively rare but are of important clinical significance because they usually indicate a worse prognosis. The most common sources are lung and colorectal cancers in males and breast and colorectal in females. In this report, we presented a chest wall skin metastasis of gastric origin in a 50-year-old male. Tumor metastasis to unusual locations such as chest wall skin and from unusual origins such as stomach is of great clinical importance.
Keywords: Gastric carcinoma, metastasis, skin
|How to cite this article:|
Abbasi F, Abbasi A, Mahmodlou R, Mehdipour E. Cutaneous metastasis of gastric carcinoma: A rare case with unusual presentation site. Indian J Dermatopathol Diagn Dermatol 2018;5:54-6
|How to cite this URL:|
Abbasi F, Abbasi A, Mahmodlou R, Mehdipour E. Cutaneous metastasis of gastric carcinoma: A rare case with unusual presentation site. Indian J Dermatopathol Diagn Dermatol [serial online] 2018 [cited 2021 May 10];5:54-6. Available from: https://www.ijdpdd.com/text.asp?2018/5/1/54/232957
| Introduction|| |
Skin metastasis is not so frequent.,, About 0.7%–10.4% of different malignancies have skin metastasis at some point of time. Colon is the most common source of primary gastrointestinal carcinoma with cutaneous metastasis., However, skin metastasis from gastric origin is relatively rare and occurs in <5% of gastric cancers.,
Here, we reported a rare case of skin metastasis of gastric carcinoma which was clinically presented by multiple skin nodules of neck and chest wall. This case is reported because of rarity of skin metastasis of gastric cancer and occurrence in relatively unusual site with unusual clinical presentation to emphasize the importance of cutaneous metastasis as a possible and also a poor prognostic sign in patients with a history of cancer.
| Case Report|| |
A 50-year-old male was admitted with dysphagia. The routine hematology and biochemistry tests were normal. Upper gastrointestinal endoscopy was performed for the patient and revealed an ulcerative mass at gastroesophageal junction (GEJ) and cardia [Figure 1]. Endoscopic biopsy from the lesion was performed. The specimen received in pathology department was composed of multiple fragments of creamy-colored soft tissue measuring 1.2 cm × 0.7 cm × 0.4 cm, totally.
|Figure 1: Endoscopic view of the patient stomach showing an ulcerative lesion with elevated periphery|
Click here to view
Microscopic examination of prepared slides stained with hematoxylin and eosin method showed proliferation of signet ring tumoral cells in mucosal and submucosal layers [Figure 2]. The diagnosis was signet ring cell carcinoma of stomach.
|Figure 2: Gastroesophageal mucosa infiltrated by malignant signet ring cells (arrows), (H and E, ×20)|
Click here to view
The patient underwent gastrectomy. Gross examination of gastrectomy specimen showed an infiltrative ulcerated tumoral area at gastric cardia with extension to GEJ measuring 8 cm in greatest diameter. Microscopic evaluation revealed signet ring cell carcinoma of stomach with penetration to gastric serosal surface (PT3). Lymphatic and perineural invasion, involvement of proximal margin, and also lymph nodes' involvement (two involved lymph nodes, PN2) were also seen. As no distant metastasis was identified during metastasis workup, the patient stage was categorized as Stage IIIB. The patient received standard chemoradiotherapy regimen for gastric carcinoma.
Nine months later, the patient admitted with multiple skin nodules on neck and chest wall. Chest radiography, brain magnetic resonance imaging, colonoscopy, and upper gastrointestinal endoscopy were normal and did not reveal any tumoral lesion.
Biopsies were taken from skin lesions, and microscopic examinations showed skin tissue infiltrated by signet ring cell carcinoma [Figure 3]a and [Figure 3]b. Histochemistry staining with periodic acid–Schiff (PAS) method revealed large malignant epithelial cells containing cytoplasmic PAS-positive material (mucin), [Figure 4]. To confirm the diagnosis, immunohistochemistry staining for CK7, CK20, and CDX2 was performed. The tumoral cells were positive for all three markers [Figure 5] and [Figure 6]. These features confirmed the diagnosis of skin involvement by metastatic signet ring cell (adeno) carcinoma of gastric origin. The patient underwent new chemotherapy treatment course but unfortunately died 1 month later.
|Figure 3: (a) Low magnitude of skin showing intact epidermis and an infiltrative area in deep dermis (arrows) (H and E, ×4). (b) higher magnitude of Figure 3a showing infiltration of malignant cells within dermis (arrow), with clear cytoplasm and signet ring features (signet ring cell carcinoma) (H and E, ×20)|
Click here to view
|Figure 4: Periodic acid–Schiff stain showing positive reaction in signet ring cells (pinkish-purple stain) showing cytoplasmic periodic acid–Schiff positive material in signet ring cell, (periodic acid–Schiff, ×40)|
Click here to view
|Figure 5: Positive staining for CK7 in immunohistochemistry staining in signet ring cells (immunohistochemistry, ×20)|
Click here to view
|Figure 6: Positive nuclear staining for CDX2 in immunohistochemistry staining in signet ring cells (immunohistochemistry, ×20)|
Click here to view
| Discussion|| |
Skin is an uncommon site for distant metastasis.,,, According to the literature, up to 10.4% of various malignancies may have cutaneous metastasis in their clinical course.,,,
The most common form of skin metastasis is adenocarcinoma, originated from lung, breast, or colon., In males, the most common solid tumors with skin metastasis are lung cancer, colorectal cancer, and malignant melanoma and in women are breast carcinoma, colorectal cancer, and malignant melanoma.,, Only 6% of all skin metastases in males and 1% in females are from gastric origin. On the other hand, skin metastasis occurs in only 0.8% of gastric cancers. Signet ring cell carcinoma is the most common form of gastric carcinoma with distant metastasis. Similarly, in our patient, skin metastasis resulted from signet ring cell carcinoma of the stomach. Secondary malignant skin tumors usually occur through the direct extension of the nearby tumor such as skin involvement in breast cancer which is usually the overlying skin tissue of the involved breast. Metastatic dissemination to skin may occur through the lymphatic channels or hematogenous spread., According to the literature, most of the reported cases of gastric skin metastases were observed in skin tissue of abdominal wall.,, In our patient, skin metastasis appeared in neck and chest wall. Skin metastasis of gastric cancer can show different clinical manifestations. Usually, as in our case, they present as skin nodules but can also be seen as erysipelas-like pattern, scirrhous carcinoma, zosteriform pattern, lesions resembling an epidermoid cyst, or even as nonspecific contact dermatitis. In general, cutaneous metastasis indicates a poor prognosis.,, The overall survival after diagnosis of skin metastasis is only a few weeks., Similarly, our patient died 1 month after diagnosis.
Skin metastasis is a very rare clinical presentation of cancers which can be seen as various nonspecific clinical presentations and so can be missed by physicians. As it is a strong sign of poor prognosis, it is recommended to be aware of this condition and take biopsies from any suspicious skin lesion in patients with a history of cancer.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
We are grateful to Mr. Ali Jafari, technician of pathology, for his assistance in processing and staining the samples.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Xavier MH, Vergueiro Tde R, Vilar EG, Pinto JM, Issa MC, Pereira GB, et al.
Cutaneous metastasis of gastric adenocarcinoma: An exuberant and unusual clinical presentation. Dermatol Online J 2008;14:8.
Prabhash K, Talwar V, Vaid AK, Doval DC. Gastric carcinoma presenting as cutaneous metastases. Indian J Dermatol Venereol Leprol 2005;71:208-9.
] [Full text]
Ahn SJ, Oh SH, Chang SE, Jeung YI, Lee MW, Choi JH, et al.
Cutaneous metastasis of gastric signet ring cell carcinoma masquerading as allergic contact dermatitis. J Eur Acad Dermatol Venereol 2007;21:123-4.
Avgerinou G, Flessas I, Hatziolou E, Zografos G, Nitsios I, Zagouri F, et al.
Cutaneous metastasis of signet-ring gastric adenocarcinoma to the breast with unusual clinicopathological features. Anticancer Res 2011;31:2373-8.
Kairouani M, Perrin J, Dietemann-Barabinot A, Diab R, Ruck S. Cutaneous metastasis revealing a relapse of gastric linitis: Another case. Int J Surg Case Rep 2013;4:185-7.
Sittart JA, Senise M. Cutaneous metastasis from internal carcinomas: A review of 45 years. An Bras Dermatol 2013;88:541-4.
Wong CY, Helm MA, Kalb RE, Helm TN, Zeitouni NC. The presentation, pathology, and current management strategies of cutaneous metastasis. N
Am J Med Sci 2013;5:499-504.
Narasimha A, Kumar H. Gastric adenocarcinoma deposits presenting as multiple cutaneous nodules: A case report with review of literature. Turk Patoloji Derg 2012;28:83-6.
Liu F, Yan WL, Liu H, Zhang M, Sang H. Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy. An Bras Dermatol 2015;90:46-50.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]